故事描述芝加哥城中最繁忙的一家医院的日常工作——这里有一支勇敢无惧的医护团队，他们团结一致，敢于面对任何风险。每当特定事件（灾难）中的病人需要救治，或者遇到别的医生束手无策的疑难杂症，就轮到他们上场了。与此同时，他们在混乱的急诊室里培养出紧密的关系并一起渡过难关。 Yaya DaCosta扮演长相迷人的住院护士Maggie Seaver，是《芝加哥烈焰》核心角色Kelly（Taylor Kinney）的新女友。事实上，他们高中时代就曾是一对恋人，但Kelly在某件事上一直亏欠她。当然，他们都经历了一段艰难岁月，因此一开始他们的关系只是单纯的友情。Severide很高兴能再见到她并与她坐下来好好谈心。S. Epatha Merkerson扮医院的负责人Sharon Goodwin。虽然管理医院的过程中时常要遇到她厌恶的「政治问题」和「权力之争」，而且她不能容忍任何胡闹的行为，但她的工作一直很出色，医院营运情况良好。Oliver Platt扮演医院精神科主任Daniel Charles。Nick Gehlfuss扮演《芝加哥警署》（Chicago PD）角色Jay Halstead的兄弟，也在这座医院中工作。Laurie Holden扮演勇敢无惧、聪明绝顶的急诊外科医生Hannah Tramble，痛苦的童年让她养成坚强彪悍的性格。在外人看来，她经常展现出「黑暗的一面」。

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